Table 4

Histologic Assessment of Aspirated Thrombus and Inflammatory/Platelet Activation Biomarkers

OverallMenWomenp Value
Aspirated thrombus, n794039
Thrombus volume, mm36 (3–15)6 (3–18)6 (2–15)0.70
Platelets presence79/79 (100)40/40 (100)39/39 (100)1.00
Average WBC, cells/5HPF75 (50–150)75 (50–200)75 (50–150)0.22
Plaque material40/79 (50.6)20/40 (50.0)20/39 (51.2)0.91
Thrombus age1.00
 Early56 (70.9)28 (70.0)28 (69.8)
 Organized23 (29.1)12 (30.0)11 (28.2)
Immunohistochemistry analysis
 MPO, cells/5HPF39 (26–90)38 (24–86)41 (26–91)0.93
 CD68, cells/5HPF20 (10–40)20 (10–50)20 (10–30)0.73
 Interleukin-5, cells/5 HPF0 (0–1)0 (0–1)0 (0–1)0.93
 CD42B score2 (2–3)2 (2–3)2 (2–3)0.18
Blood biomarkers, n1296564
 CRP, mg/l2.08 (1.00–4.11)1.64 (0.88–4.77)2.21 (1.01–4.02)0.49
 MPO, ng/ml604.2 (290.5–1,496.9)512.7 (271.4–1,308.7)956.7 (303.7–1,658.7)0.09
 ECP, μg/l5.0 (2.8–9.1)5.1 (2.5–10.5)4.5 (2.9–7.9)0.65
 TBX2, pg/ml117.2 (60.6–256.1)117.2 (58.5–189.1)117.3 (62.9–261.6)0.63

Values are median (interquartile range), n/N (%), or n (%).

5HPF = 5 high-power field; CRP = C-reactive protein; ECP = eosinophil cationic protein; MPO = myeloperoxidase; TBX2 = thromboxane-B2; WBC = white blood cells.

  • The CD42B score employed a scale of 0 to 3 where 0 = no platelets, 1 ≤ one-third of the thrombus area, 2 ≤ one- to two-thirds of the thrombus area, and 3 ≥ two-thirds of the thrombus area.