Table 1

Selection of Studies on the Use of PCI for TCAD in Cardiac Transplant Recipients

First Author (Ref. #)No. of Patients/No. of Stented LesionsProcedural Success Rate (<50% residual stenosis)Mean, Median, or Stated Follow-Up TimePatients With Adverse Clinical Outcome During Follow-UpRestenosis Rates of BMS and DES or Freedom From Restenosis RatesNotes
Bader et al. (28)40/78 (65 BMS, 13 DES)91%40.8 ± 34.5 months8 (20%): 6 deaths, 2 repeat OHT31% vs. 15% (p = 0.27)
Simpson et al. (90)33/34 (97 PCI, 63 balloon angioplasty alone)99%6 months, 12 months, and 5 yrs39.3% died or retransplanted after mean 1.9 ± 2.3 yrs after first PCIBMS vs. balloon angioplasty: 6 months: 31% vs. 41%, 12 months: 46% vs. 53%, 5 yrs: 69% vs. 68%
Benza et al. (91)62/219 lesions97%Angiographic follow-up at 3–6 months, then annuallyRepeat PCI rate 34%, PCI-related death rate 2.6%Freedom from restenosis: 95% at 1 month, 81% at 3 months, 57% at 6 months2-yr freedom from TCAD or graft loss was 74% with 1-vessel disease at time of first PCI, 75% for 2-vessel, and 27% for 3-vessel
Wellnhofer et al. (92)160 patients (227 BMS, 66 DES, 209 balloon angioplasty alone)97%Clinical: 9.9 ± 4.4 yrs Angiographic: 28 ± 30 months38% restenosis rate
Lee et al. (96)82 patients, 158 PCI (98 BMS, 80 DES)100%Angiographic only: 70% of BMS lesions at 9.5 ± 5.5 months, 76% of DES lesions at 12.6 ± 8.2 months20% with adverse outcomeBinary restenosis rate: 30% BMS vs. 12% DES (p = 0.02)No angiographic stent thrombosis observed with DES
Zakliczynski et al. (97)13 patients with 24 BMS, 17 patients with 28 DES, 7 patients with both BMS and DES20 months for BMS, 14 months for DES3 deaths (18%) among DES, 4 (31%) with BMS, and 1 (14%) with DES and BMS (p = NS)DES: 7%, BMS: 58%Longer time of freedom from ISR after PCI with DES (p = 0.022). No angiographic stent thrombosis observed with DES

BMS = bare metal stents; DES = drug-eluting stents; ISR = in-stent restenosis; PCI = percutaneous coronary intervention; TCAD = transplant coronary artery disease.