Author + information
- Received November 8, 2013
- Accepted November 21, 2013
- Published online February 1, 2015.
- ∗Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, Michigan
- †Department of Cardiovascular Medicine, William Beaumont Hospital, Royal Oak, Michigan
- ↵∗Reprint requests and correspondence:
Dr. Robert D. Safian, Department of Cardiovascular Medicine, William Beaumont Hospital, 3601 West 13 Mile Road, Royal Oak, Michigan 48073.
Lipid-core plaque (LCP) detected by near-infrared spectroscopy (NIRS) in the coronary arteries is associated with acute coronary syndromes (ACS) (1,2). Analogous to its role in acute coronary syndromes, LCP in the carotid arteries has been implicated in the pathogenesis of stroke (3). It has not been previously demonstrated whether NIRS, which was developed to identify LCP in the coronary arteries, can also detect LCP in the carotid arteries.
We performed NIRS in the carotid arteries of patients with severe carotid stenosis after deployment of a distal embolic protection device but prior to stenting. The present observations represent the first-in-man use of NIRS to characterize carotid artery plaque in vivo and demonstrate the feasibility of carotid NIRS imaging (Figures 1 and 2⇓⇓). Future studies are needed to determine whether NIRS can predict procedural complications during carotid stenting, influence the selection of patients for stenting or endarterectomy, and predict future neurologic events.
Dr. Madder has received research support and speaker honoraria from Infraredx, Inc.; and has served as a consultant for St. Jude Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received November 8, 2013.
- Accepted November 21, 2013.
- American College of Cardiology Foundation
- Madder R.D.,
- Smith J.L.,
- Dixon S.R.,
- Goldstein J.A.
- Gupta A.,
- Baradaran H.,
- Schweitzer A.D.,
- et al.