Author + information
- Received February 1, 2012
- Revision received February 23, 2012
- Accepted March 29, 2012
- Published online August 1, 2012.
- Shengxian Tu, PhD⁎,⁎ (, )
- Niels R. Holm, MD†,
- Evald H. Christiansen, MD, PhD† and
- Johan H.C. Reiber, PhD⁎
- ↵⁎Reprint requests and correspondence:
Dr. Shengxian Tu, Division of Image Processing, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands
Correct characterization of coronary bifurcations by optical coherence tomography (OCT) is essential for evaluation of lesions and treatment. Assessment is limited by the need for acquiring images in both the main branch (MB) and the side branch (SB) and the risk of OCT cross sections not being perpendicular to the true vessel centerline due to imaging wires being nonparallel to the centerline. We present a new method for evaluation of coronary bifurcations by fusion of x-ray angiography (XA) and OCT acquired in the MB. XA in 2 projections was reconstructed in 3 dimensions (3D) and fused with OCT using Medis prototype software (1). Evaluation of the SB ostium (Fig. 1, panels 1 to 5) was performed by reconstructed OCT cross sections perpendicular to the XA-constructed SB vessel centerline. In the presented case, the area of the SB ostium was 1.78 mm2 by 3D quantitative coronary angiography and was 1.67 mm2 by OCT in the plane perpendicular to the SB centerline (Fig. 1, panel 2).
Fusion of 3D-reconstructed XA and centerline-adjusted OCT may improve evaluation of tortuous vessels and ostial lesions, and might limit the need for SB acquisitions in bifurcation lesion assessments.
Dr. Tu is employed by Medis Medical Imaging Systems BV and has a research appointment at the Leiden University Medical Center (LUMC). Dr. Holm reports receiving unrestricted research grants from Boston Scientific and unrestricted research grants and speaker fees from St. Jude Medical and travel grants from Abbott Vascular. Dr. Christiansen reports receiving speaker fees from St. Jude Medical and travel grants from Abbott Vascular. Dr. Reiber is the CEO of Medis medical imaging systems bv, and has a part-time appointment at LUMC as Professor of Medical Imaging. The first two authors contributed equally to this work.
- Received February 1, 2012.
- Revision received February 23, 2012.
- Accepted March 29, 2012.
- American College of Cardiology Foundation
- Tu S.,
- Xu L.,
- Ligthart J.,
- et al.